Hyperglycemia associated with protease inhibitors in HIV-1-infected patients
نویسندگان
چکیده
منابع مشابه
HIV-1 protease inhibitors.
Treatment of human immunodeficiency virus type 1 (HIV-1) infection with regimens that include protease inhibitors (PIs) has contributed to marked improvements in HIV-related disease progression and mortality. Five PIs are approved by the US Food and Drug Administration and have potent activity in vitro. PIs with 2 nucleoside analogue reverse transcriptase inhibitors have demonstrated prolonged ...
متن کاملAtherogenic Dyslipidemia in HIV-Infected Individuals Treated With Protease Inhibitors
Background—Administration of protease inhibitors (PIs) to HIV-infected individuals has been associated with hyperlipidemia. In this study, we characterized the lipoprotein profile in subjects receiving ritonavir, indinavir, or nelfinavir, alone or in combination with saquinavir. Methods and Results—Plasma lipoprotein levels were quantified in 93 HIV-infected adults receiving PIs. Comparison was...
متن کاملMutations associated with virological response to darunavir/ritonavir in HIV-1-infected protease inhibitor-experienced patients.
OBJECTIVE The aim of the study was to identify a pattern of protease gene mutations associated with the virological response to darunavir/ritonavir-based regimens. PATIENTS AND METHODS We analysed 153 treatment-experienced patients receiving a darunavir/ritonavir salvage regimen as a sole protease inhibitor (PI). Virological response was defined as an HIV-1 RNA load of <200 copies/mL at month...
متن کاملWhole body leucine flux in HIV-infected patients treated with or without protease inhibitors.
The present study was carried out to assess the effects of protease inhibitor (PI) therapy on basal whole body protein metabolism and its response to acute amino acid-glucose infusion in 14 human immunodeficiency virus (HIV)-infected patients. Patients treated with PIs (PI+, 7 patients) or without PIs (PI-, 7 patients) were studied after an overnight fast during a 180-min basal period followed ...
متن کاملSafety of protease inhibitors in HIV-infected pregnant women
The dire conditions of the human immunodeficiency virus/acquired immune deficiency syndrome epidemic and the immense benefits of antiretroviral prophylaxis in prevention of mother-to-child transmission far outweigh the potential for adverse effects and undeniably justify the rapid and widespread use of this therapy, despite incomplete safety data. Highly active antiretroviral therapy has now be...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2000
ISSN: 1198-743X
DOI: 10.1046/j.1469-0691.2000.00083.x